Yorick Brown, the last man on Earth, has finally reached the country where his fiancée Beth has been stranded since the male-killing plague struck more than three years ago. Unfortunately, the visit is just a stopover -- the trail that has lead Yorick to the shores of Australia continues on to Japan, where Yorick's pet monkey Ampersand, the only other male mammal to survive the plague and the possible key to its cure, has been taken.

More than two years after an unexplained plague killed every other male mammal on the planet, with two exceptions - aspiring escape artist Yorick Brown and his pet monkey Ampersand - have traveled across the remains of the U.S with biochemist Dr. Allison Mann and government operative Agent 355 to Dr. Mann's lab in San Francisco, where she managed to finally isolate the source of their immunity. Unfortunately, that source is within Ampersand's body,...

The Runaways say good-bye to the past and make hard decisions about their future. Plus: Still reeling from the events of Civil War, Young Avengers/Runaways, the teenage heroes must now confront a horrible enemy who threatens to tear them apart!

"In this final volume, Yorick and Agent 355 prepare for their ultimate quest to reunite the last man with his lost love, while the person, people or thing behind the disaster that wiped out half of humanity is revealed. Then, Yorick Brown's long journey through an Earth populated only by women comes to a dramatic, unexpected conclusion. Collects Y: THE LAST MAN #49-60"--