Nearly four years after a plague killed all the other males on Earth, Yorick and his friends have tracked his monkey, Ampersand, to Japan. There, they must navigate a tricky maze of Yakuza remnants, gangsters, and pop stars to retrieve the monkey, whose DNA may hold the key to repopulating the Earth.

In 2002, the world changes forever. Every man, every boy, every mammal with a Y chromosome everywhere on Earth suddenly collapses and dies. With the loss of nearly half the planet's population, the gears of society grind to a halt, and a world of women are left to pick up the pieces and try to keep civilization from collapsing entirely. The "gendercide," however, is not absolutely complete. For some unknown reason, one young man named Yorick Brown...