A deranged serial killer called Mister Sleep, survives prison execution and is reborn as a terrifying and unstoppable force of nature who unleashes savage and bloody revenge on a group of insomnia patients participating in a new drug trial - a group who he believes have stolen his memories. His relentless thirst for revenge sets him on a collsion course with the man who sent him to death row and his young daughter, who is part of the group testing...

Inspired by real events, this film is set over a 24-hour period in Florida during the winter of 1978 when a serial killer was stalking college girls.